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1

The Role of Oxidative Stress in Cerebral Cavernous Malformation (CCM) Pathogenesis: From Disease Mechanisms toward Therapeutic Approaches

Trapani, Eliana, Marchi, Saverio, Choquet, Helene, Goitre, Luca, Moglia, Andrea, Antognelli, Cinzia, Delle Monache, Simona, Trabalzini, Lorenza, Kim, Helen, Pinton, Paolo, Francesco Retta, Saverio

Journal:

Free Radical Biology and Medicine

Année:

2015

Langue:

english

Fichier:

PDF, 174 KB

english, 2015

2

Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases

Perrelli, Andrea, Goitre, Luca, Salzano, Anna Maria, Moglia, Andrea, Scaloni, Andrea, Retta, Saverio Francesco

Journal:

Oxidative Medicine & Cellular Longevity

Année:

2018

Langue:

english

Fichier:

PDF, 2.59 MB

english, 2018

3

[Methods in Molecular Biology] Cerebral Cavernous Malformations (CCM) Volume 2152 (Methods and Protocols) ||

Trabalzini, Lorenza, Finetti, Federica, Retta, Saverio Francesco

Année:

2020

Fichier:

PDF, 13.88 MB

2020

4

Production of novel antioxidative phenolic amides through heterologous expression of the plant’s chlorogenic acid biosynthesis genes in yeast

Moglia Andrea, Comino Cinzia, Lanteri Sergio, de Vos Ric, de Waard Pieter, van Beek Teris A., Goitre Luca, Retta Saverio Francesco, Beekwilder Jules

Journal:

Metabolic Engineering

Année:

2010

Langue:

english

Fichier:

PDF, 491 KB

english, 2010

5

A Unique Interplay Between Rap1 and E-Cadherin in the Endocytic Pathway Regulates Self-Renewal of Human Embryonic Stem Cells

Li Li, Shuai Wang, Anna Jezierski, Lilian Moalim-Nour, Kanishka Mohib, Robin J. Parks, Saverio Francesco Retta, Lisheng Wang

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 996 KB

english, 2010

6

Rap1: A turnabout for the crosstalk between cadherins and integrins

Saverio Francesco Retta, Fiorella Balzac, Maria Avolio

Journal:

European Journal of Cell Biology

Année:

2006

Langue:

english

Fichier:

PDF, 592 KB

english, 2006

7

Structural and functional differences between KRIT1A and KRIT1B isoforms: A framework for understanding CCM pathogenesis

Floriana Francalanci, Maria Avolio, Elisa De Luca, Dario Longo, Valeria Menchise, Paolo Guazzi, Francesco Sgrò, Marco Marino, Luca Goitre, Fiorella Balzac, Lorenza Trabalzini, Saverio Francesco Retta

Journal:

Experimental Cell Research

Année:

2009

Langue:

english

Fichier:

PDF, 6.02 MB

english, 2009

8

ß1B Integrin interferes with matrix assembly but not with confluent monolayer polarity, and alters some morphogenetic properties of FRT epithelial cells

Gaetano Calí, Saverio Francesco Retta, Rosa Negri, Ivana Damiano, Raffaele Gentile, Guido Tarone, Lucio Nitsch, Corrado Garbi

Journal:

European Journal of Cell Biology

Année:

1998

Langue:

english

Fichier:

PDF, 1.89 MB

english, 1998

9

The Muscle-Specific Laminin Receptor α7β1 Integrin Negatively Regulates α5β1 Fibronectin Receptor Function

Daniela Tomatis, Frank Echtermayer, Stephan Schöber, Fiorella Balzac, Saverio Francesco Retta, Lorenzo Silengo, Guido Tarone

Journal:

Experimental Cell Research

Année:

1999

Langue:

english

Fichier:

PDF, 722 KB

english, 1999

10

Identification of Krit1B: a novel alternative splicing isoform of cerebral cavernous malformation gene-1

Saverio Francesco Retta, Maria Avolio, Floriana Francalanci, Simone Procida, Fiorella Balzac, Simona Degani, Guido Tarone, Lorenzo Silengo

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2004

11

[Methods in Molecular Biology] Ras Signaling Volume 1120 ||

Trabalzini, Lorenza, Retta, Saverio Francesco

Année:

2014

Langue:

english

Fichier:

PDF, 8.32 MB

english, 2014

12

[Methods in Molecular Biology] Ras Signaling Volume 1120 || Methods to Study the Ras2 Protein Activation State and the Subcellular Localization of Ras-GTP in Saccharomyces cerevisiae

Trabalzini, Lorenza, Retta, Saverio Francesco

Année:

2014

Langue:

english

Fichier:

PDF, 222 KB

english, 2014

13

miR-21 coordinates tumor growth and modulates KRIT1 levels

Orso, Francesca, Balzac, Fiorella, Marino, Marco, Lembo, Antonio, Retta, Saverio Francesco, Taverna, Daniela

Journal:

Biochemical and Biophysical Research Communications

Année:

2013

Langue:

english

Fichier:

PDF, 483 KB

english, 2013

14

KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun

Goitre, Luca, De Luca, Elisa, Braggion, Stefano, Trapani, Eliana, Guglielmotto, Michela, Biasi, Fiorella, Forni, Marco, Moglia, Andrea, Trabalzini, Lorenza, Retta, Saverio Francesco

Journal:

Free Radical Biology and Medicine

Année:

2014

Langue:

english

Fichier:

PDF, 7.20 MB

english, 2014

15

[Methods in Molecular Biology] Ras Signaling Volume 1120 || Analysis of Rho GTPase-Induced Localization of Nanoscale Adhesions Using Fluorescence Nanoscopy

Trabalzini, Lorenza, Retta, Saverio Francesco

Année:

2014

Langue:

english

Fichier:

PDF, 593 KB

english, 2014

16

The Interplay between ROS and Ras GTPases: Physiological and Pathological Implications

Ferro, Elisa, Goitre, Luca, Retta, Saverio Francesco, Trabalzini, Lorenza

Journal:

Journal of Signal Transduction

Année:

2012

Langue:

english

Fichier:

PDF, 122 KB

english, 2012

17

Reactive Oxygen Species: Friends and Foes of Signal Transduction

Retta, Saverio Francesco, Chiarugi, Paola, Trabalzini, Lorenza, Pinton, Paolo, Belkin, Alexey M.

Journal:

Journal of Signal Transduction

Année:

2012

Langue:

english

Fichier:

PDF, 35 KB

english, 2012

18

Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?

Goitre, Luca, Pergolizzi, Barbara, Ferro, Elisa, Trabalzini, Lorenza, Retta, Saverio Francesco

Journal:

Journal of Signal Transduction

Année:

2012

Langue:

english

Fichier:

PDF, 595 KB

english, 2012

19

Evaluation of the bioactive properties of avenanthramide analogs produced in recombinant yeast

Moglia, Andrea, Goitre, Luca, Gianoglio, Silvia, Baldini, Eva, Trapani, Eliana, Genre, Andrea, Scattina, Antonella, Dondo, Giancarlo, Trabalzini, Lorenza, Beekwilder, Jules, Retta, Saverio Francesco

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 923 KB

english, 2015

20

The Integrin Cytoplasmic Domain-Associated Protein ICAP-1 Binds and Regulates Rho Family GTPases during Cell Spreading

Simona Degani, Fiorella Balzac, Mara Brancaccio, Simona Guazzone, Saverio Francesco Retta, Lorenzo Silengo, Alessandra Eva and Guido Tarone

Journal:

The Journal of Cell Biology

Année:

2002

Langue:

english

Fichier:

PDF, 3.42 MB

english, 2002

21

Platinum nanozymes recover cellular ROS homeostasis in oxidative stress-mediated disease model

Moglianetti, Mauro, De Luca, Elisa, Pedone, Deborah, Marotta, Roberto, Catelani, Tiziano, Sartori, Barbara, Amenitsch, Heinz, Retta, Saverio Francesco, Pompa, Pier Paolo

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2016

22

Cytochrome P450 and Matrix Metalloproteinase Genetic Modifiers of Disease Severity in Cerebral Cavernous Malformation type 1

Choquet, Hélène, Trapani, Eliana, Goitre, Luca, Trabalzini, Lorenza, Akers, Amy, Fontanella, Marco, Hart, Blaine L., Morrison, Leslie A., Pawlikowska, Ludmila, Kim, Helen, Retta, Saverio Francesco

Journal:

Free Radical Biology and Medicine

Année:

2016

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2016

23

Cellular processes underlying cerebral cavernous malformations: Autophagy as another point of view

Marchi, Saverio, Retta, Saverio Francesco, Pinton, Paolo

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 642 KB

english, 2016

24

Inhibition of PI3K induces Rac Activation and Membrane Ruffling in Proto-Dbl Expressing Cells

Vanni, Cristina, Visco, Vincenzo, Parodi, Alessia, Ottaviano, Catherine, Ognibene, Marzia, Manazza, Andrea D, Retta, Saverio Francesco, Varesio, Luigi, Mancini, Patrizia, Torrisi, Maria Rosaria, Eva,

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 995 KB

english, 2006

25

Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies

Marchi, Saverio, Trapani, Eliana, Corricelli, Mariangela, Goitre, Luca, Pinton, Paolo, Retta, Saverio Francesco

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 704 KB

english, 2016

26

Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin

Retta, Saverio Francesco, Glading, Angela J.

Journal:

The International Journal of Biochemistry & Cell Biology

Année:

2016

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2016

27

Altered redox signaling and oxidative stress: the emerging faces of Cerebral Cavernous Malformation (CCM) pathogenesis

Retta, Saverio Francesco

Journal:

Free Radical Biology and Medicine

Année:

2016

Langue:

english

Fichier:

PDF, 209 KB

english, 2016

28

Loss of KRIT1 causes a sustained activation of an adaptive cellular allostatic response that counteracts intrinsic oxidative stress but sensitizes cells to further oxidative challenges

Francesco Retta, Saverio

Journal:

Free Radical Biology and Medicine

Année:

2017

Langue:

english

Fichier:

PDF, 44 KB

english, 2017

29

Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function

Antognelli, Cinzia, Trapani, Eliana, Delle Monache, Simona, Perrelli, Andrea, Fornelli, Claudia, Retta, Francesca, Cassoni, Paola, Talesa, Vincenzo Nicola, Retta, Saverio Francesco

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2018

30

NADPH oxidase regulates the expression of angiogenic growth factors in Cerebral Cavernous Malformation cellular models

Schiavo, Irene, Ercoli, Jasmine, Finetti, Federica, Trapani, Eliana, Retta, Saverio Francesco, Trabalzini, Lorenza

Journal:

Free Radical Biology and Medicine

Année:

2018

Langue:

english

Fichier:

PDF, 61 KB

english, 2018

31

Identification of the Kelch Family Protein Nd1-L as a Novel Molecular Interactor of KRIT1

Guazzi, Paolo, Goitre, Luca, Ferro, Elisa, Cutano, Valentina, Martino, Chiara, Trabalzini, Lorenza, Retta, Saverio Francesco, Cotterill, Sue

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 3.02 MB

english, 2012

32

Oxidative Stress and inflammation in cerebral cavernous malformation disease pathogenesis: Toward a unifying mechanistic and therapeutic landscape

Retta, Saverio Francesco

Journal:

Free Radical Biology and Medicine

Année:

2018

Langue:

english

Fichier:

PDF, 38 KB

english, 2018

33

Altered redox homeostasis and signaling in Cerebral Cavernous Malformation disease: towards a complex but unifying pathogenic mechanism and therapeutic implications

Trapani, Eliana, Antognelli, Cinzia, Goitre, Luca, Perrelli, Andrea, Sarri, Sara, Barrera, Giuseppina, Talesa, Vincenzo, Trabalzini, Lorenza, Retta, Saverio Francesco

Journal:

Free Radical Biology and Medicine

Année:

2018

Fichier:

PDF, 75 KB

2018

34

Altered redox homeostasis and signaling in Cerebral Cavernous Malformation disease: towards a complex but unifying pathogenic mechanism and therapeutic implications

Trapani, Eliana, Antognelli, Cinzia, Goitre, Luca, Perrelli, Andrea, Sarri, Sara, Barrera, Giuseppina, Talesa, Vincenzo, Trabalzini, Lorenza, Retta, Saverio Francesco

Journal:

Free Radical Biology and Medicine

Année:

2018

Langue:

english

Fichier:

PDF, 75 KB

english, 2018

35

Multifunctional Platinum@BSA–Rapamycin Nanocarriers for the Combinatorial Therapy of Cerebral Cavernous Malformation

De Luca, Elisa, Pedone, Deborah, Moglianetti, Mauro, Pulcini, Daniele, Perrelli, Andrea, Retta, Saverio Francesco, Pompa, Pier Paolo

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 3.13 MB

english, 2018

36

Intracellular Antioxidant Activity of Biocompatible Citrate-Capped Palladium Nanozymes

Moglianetti, Mauro, Pedone, Deborah, Udayan, Gayatri, Retta, Saverio Francesco, Debellis, Doriana, Marotta, Roberto, Turco, Antonio, Rella, Simona, Malitesta, Cosimino, Bonacucina, Giulia, De Luca, El

Journal:

Année:

2020

Fichier:

PDF, 3.49 MB

2020

37

KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses

Finetti, Federica, Schiavo, Irene, Ercoli, Jasmine, Zotta, Alessia, Boda, Enrica, Retta, Saverio Francesco, Trabalzini, Lorenza

Journal:

Cellular Signalling

Année:

2020

Fichier:

PDF, 7.31 MB

2020

38

Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations

Antognelli, Cinzia, Perrelli, Andrea, Armeni, Tatiana, Nicola Talesa, Vincenzo, Retta, Saverio Francesco

Journal:

Année:

2020

Langue:

english

Fichier:

PDF, 831 KB

english, 2020

39

Vitamin D Deficiency and the Risk of Cerebrovascular Disease

Kim, Hyun Ah, Perrelli, Andrea, Ragni, Alberto, Retta, Francesca, De Silva, T. Michael, Sobey, Christopher G., Retta, Saverio Francesco

Journal:

Année:

2020

Fichier:

PDF, 1.65 MB

2020